Could not load file or assembly ‘‘ or one of its dependencies. There is not enough space on the disk

We got the following error in one of our application server nodes.

Could not load file or assembly '' or one of its dependencies. There is not enough space on the disk (Exception from HRESULT: 0x80070070)

At first, (as the error explains) when I checked the disk space, it was very less. It was less than 500 MB. All the applications from that app. server node throwing the similar error. Then I referred this and free some space. It looked fine. Now the free space was around 3 GB. Then notified client.

After sometime, got an angry email from Client saying the problem still exists. When I checked again, the same problem persists. Funny thing is, this time, only one application is throwing the error. Other applications from the same node worked fine. Only diff. between those application is the .NET framework. The free space is still the same (around 3 GB).

This time, cleared all the applications under <.NET Framework Folder>\Temporary ASP.NET Files. It worked again.

Still I couldn’t relate the fix I did, to the error message received.